Obesity is a condition of increasing amount of body fat and associated with body mass index. Obesity increase leptin levels and one of the indicators that caused hypothalamus damage and leading to insulin resistance. The function of insulin is to suppress the production of blood glucose levels. Obesity also makes the uric acid level to increase by production of xanthine oxidoreductase. Similarly, cholesterol levels are increased due to the hydrolysis process of triglycerides into low density lipoprotein. The purpose of this study was to determine the relationship of obesity with elevated blood glucose, uric acid, and cholesterol at RSUD Al-Ihsan of Bandung. This research was conducted from 2015-2017. The research methode is analitycal observational with cross-sectional design. The sample of research were 20 people with obese and 20 people without obese. All of them observed the level of blood glucose, uric acid, and cholesterol. As for mann-whitney test and t-independent test results, it was shown that the blood glucose level had p=0,174, uric acid level had p=0,065, and cholesterol level had p=0,109 or p>0,05. In conclusion, there is no relationship between obesity with glood glucose level, uric acid level, and cholesterol level.Obesitas didefinisikan sebagai jumlah lemak yang terlalu tinggi di dalam tubuh yang berkaitan dengan indeks masa tubuh. Obesitas meningkatkan kadar leptin dan merusak hipotalamus sehingga terjadi resistensi insulin. Insulin berfungsi untuk menekan produksi gula darah. Pada orang obesitas nafsu makan cenderung meningkat sehingga terjadi peningkatan kadar gula darah. Obesitas dapat meningkatkan produksi xanthin oxidoreductase sehingga kadar asam urat meningkat akibat proses hidrolisis trigliserid menjadi low density lipoprotein. Tujuan penelitian ini adalah untuk mengetahui hubungan obesitas dengan peningkatan kadsr gula darah, asam urat dan kolesterol di RSUD Al Ihsan Bandung periode 2015-2017. Metode yang digunakan adalah observasional analitik dengan pendekatan cross sectional. Hasil uji man-whitney dan t tidak berpasangan menunjukan bahwa tidak terdapat hubungan obesitas dengan kadar gula darah dengan nilai p=0,174, asam urat dengan nilai p=0,065, dan kolesterol dengan nilai p=0,109 atau p>0,05. Kesimpulan tidak terdapat hubungan antara obesitas dengan kadar gula darah, asam urat, dan kolesterol.