| dc.contributor |
Fakultas Kedokteran |
|
| dc.creator |
Athalarik, Faisal Akbar |
|
| dc.creator |
Tejasari, Maya |
|
| dc.creator |
Muflihah, Heni |
|
| dc.date |
2020-01-27 |
|
| dc.date.accessioned |
2020-07-13T03:17:54Z |
|
| dc.date.available |
2020-07-13T03:17:54Z |
|
| dc.identifier |
http://karyailmiah.unisba.ac.id/index.php/dokter/article/view/21287 |
|
| dc.identifier.uri |
http://hdl.handle.net/123456789/27367 |
|
| dc.description |
Abstract. Kidney is the main excretory organ that has an important role in the human body. Damage to the kidneys can be fatal, especially damage to kidney function, so the filtration and reabsorption process does not work perfectly. 7,12-dimethylbenz- [a] anthracene (DMBA) is a toxic substance that can induce cancer and cause nephrotoxicity. Kidneys that have been exposed to DMBA will correct changes such as dilation of the bowman's capsule. It is known, the leaves of the soursop plant (Annona muricata) can increase the antioxidant Nrf-2 and release anti-inflammatory factors. The purpose of this study was to analyze how to apply soursop leaf extract to the average size of the Bowman capsule of rat kidneys. A total of 17 Wistar strain rats were used as experimental animals. This research is purely in vivo experimental research and data analysis using Anova test. Research data taken by observing rat kidney preparations that have been given assistance with a light microscope with the help of Image Raster application. The results showed the effect of doses which affected the size of the Bowman's capsule in rats. The results of statistical analysis showed a link between the deciding groups and the size of capsules. Bowman was rejected because of the value of p = 0.07 (p value> 0.05). Conclusion, give soursop leaf water extract to rats that have been induced by DMBA has no relationship statistically reviewed.Keyword: Cancer, Annona muricata, DMBA, DMBA effect to KidneAbstrak. Ginjal merupakan organ ekskresi utama yang memiliki peran penting dalam tubuh manusia. Kerusakan pada ginjal dapat berakibat fatal, terutama kerusakan pada fungsi ginjal, sehingga proses filtrasi dan reabsorpsi tidak berlangsung sempurna. 7,12-dimethylbenz-[a]anthracene (DMBA) merupakan zat toksik yang dapat menginduksi kanker dan menyebabkan nephrotoxicity. Ginjal yang telah terpapar DMBA akan mengalami perubahan seperti dilatasi kapsula bowman. Telah diketahui, daun dari tumbuhan sirsak (Annona muricata) dapat meningkatkan antioxidant Nrf- 2 dan mengeluarkan faktor antiinflamasi. Tujuan penelitian untuk menganalisis pengaruh pemberian ekstrak daun sirsak terhadap rerata ukuran kapsula Bowman ginjal tikus. Sebanyak 17 tikus galur Wistar digunakan sebagai hewan coba. Penelitian ini merupakan penelitian eksperimental murni in vivo dan analisis data dengan uji Anova. Data penelitian diambil dengan cara melakukan observasi pada preparat ginjal tikus yang telah diberikan serangkaian perlakuan menggunakan mikroskop cahaya dengan bantuan aplikasi Image Raster. Hasil penelitian menunjukkan adanya dose dependent yang mempengaruhi ukuran kapsula Bowman ginjal tikus. Hasil analisis statistik menunjukan bahwa praduga adanya keterkaitan antara kelompok perlakuan dengan ukuran kapsula Bowman ditolak karena adanya nilai p=0.07 (nilai p>0.05). Simpulan, pemberian ekstrak air daun sirsak pada tikus yang telah diinduksi DMBA tidak memiliki keterkaitan ditinjau secara statistik.Kata Kunci: Kanker, Daun sirsak, DMBA, DMBA terhadap Ginjal |
|
| dc.format |
application/pdf |
|
| dc.language |
eng |
|
| dc.publisher |
Universitas Islam Bandung |
|
| dc.relation |
http://karyailmiah.unisba.ac.id/index.php/dokter/article/view/21287/pdf |
|
| dc.rights |
Copyright (c) 2020 Prosiding Pendidikan Dokter |
|
| dc.source |
Prosiding Pendidikan Dokter; Vol 6, No 1, Prosiding Pendidikan Dokter (Februari, 2020); 498-502 |
|
| dc.source |
Prosiding Pendidikan Dokter; Vol 6, No 1, Prosiding Pendidikan Dokter (Februari, 2020); 498-502 |
|
| dc.source |
2460-657X |
|
| dc.subject |
Pendidikan Kedokteran |
|
| dc.subject |
Kanker, Daun sirsak, DMBA, DMBA terhadap Ginjal |
|
| dc.title |
Ekstrak Air Daun Sirsak mempengaruhi Mikrostruktur Kapsula Bowman secara Dose Dependent Manner pada Tikus yang Diinduksi 7,12-Dimethylbenz-[A]Anthracene (DMBA) |
|
| dc.type |
info:eu-repo/semantics/article |
|
| dc.type |
info:eu-repo/semantics/publishedVersion |
|
| dc.type |
Peer-reviewed Article |
|
| dc.type |
Kuantitatif |
|