| dc.contributor |
Fakultas Matematika dan Ilmu Pengetahuan Alam |
|
| dc.creator |
Maryawan, Irman |
|
| dc.creator |
Effendi, Diar Herawati |
|
| dc.creator |
Fakih, Taufik Muhammad |
|
| dc.date |
2020-08-25 |
|
| dc.date.accessioned |
2021-03-15T03:41:31Z |
|
| dc.date.available |
2021-03-15T03:41:31Z |
|
| dc.identifier |
http://karyailmiah.unisba.ac.id/index.php/farmasi/article/view/24029 |
|
| dc.identifier |
10.29313/.v6i2.24029 |
|
| dc.identifier.uri |
http://hdl.handle.net/123456789/28742 |
|
| dc.description |
Abstract. Encephalitis is an inflammation of the brain caused by parenchymal virus infection. There is another cause of encephalitis which is caused by autoimmune. NMDA receptors are receptors responsible for encephalitis. Hydroxyproline is an amino acid resulting from modification of the amino acid proline. So, hydroxyproline becomes an important metabolite in immunulogical encephalitis at the NMDA receptor. The purpose of this study was to study safety based on the activity between hydroxrolin composition of NMDA receptors in silico compared to their natural ligands. In this study a trial was carried out on NMDA silico encephalitis reactivity receptors against hydroxyproline using a protein-ligand based molecular inhibition method. NMDA receptors and natural ligands are taken first. The best reform simulation was chosen for docking simulation of NMDA receptors. Based on the results of the research, it shows that hydroxyproline compounds have a low risk of security to NMDA receptors because of the docking results obtained free energy bond (∆G) of -4.91 Kcal/mol, compared to natural ligand (d-serine) of -6.35 Kcal/mol. It is predicted that the affinity of hydroxyproline bonds to the receptor is very strong and has a low risk of security, supported by the parameters of the cramer rule is the High (Class III) category.Keywords: Encephalitis, Hydoxyproline, NMDA receptorAbstrak. Ensefalitis adalah inflamasi pada parenkim otak yang disebabkan oleh infeksi virus. Terdapat penyebab ensefalitis lain yaitu disebakan oleh autoimun. Reseptor NMDA adalah reseptor yang bertanggung jawab terhadap ensefalitis. Hidroksiprolin adalah asam amino hasil dari modifikasi asam amino prolin, sehingga hidroksiprolin merupakan metabolit yang penting dalam ensefalitis imunulogi pada reseptor NMDA. Tujuan dari penelitian ini adalah untuk melakukan study keamanan berdasarkan aktivitas antara senyawa hidrosiprolin terhadap reseptor NMDA secara in silico yang dibandingkan dengan ligan alaminya. Dalam penelitian ini dilakukan uji in silico reaktivitas reseptor NMDA ensefalitis terhadap hidroksiprolin menggunakan motode penambatan molekular berbasis ligan-protein. Reseptor NMDA dan ligan alami dipisahkan terlebih dahulu. Konformasi senyawa uji terbaik dipilih untuk dilakukan simulasi docking terhadap reseptor NMDA. Berdarkan hasil penelitian, menunjukan senyawa hidroksiprolin memiliki resiko keamaanan yang rendah terhadap reseptor NMDA karena dari hasil docking didapat energi bebas ikatan (∆G) sebesar -4,91 Kcal/mol, dibanding ligan alami (d-serine) sebesar -6.35 Kcal/mol. Diprediksi afinitas ikatan hidroksiprolin terhadap reseptor sangat kuat dan memiliki resiko keamaanan yang rendah, didukung dengan parameter cramer rules masuk kategori High (Class III).Kata Kunci: Ensefalitis, Hidroksiprolin, Reseptor NMDA |
|
| dc.format |
application/pdf |
|
| dc.language |
eng |
|
| dc.publisher |
Universitas Islam Bandung |
|
| dc.relation |
http://karyailmiah.unisba.ac.id/index.php/farmasi/article/view/24029/pdf |
|
| dc.rights |
Copyright (c) 2020 Prosiding Farmasi |
|
| dc.source |
Prosiding Farmasi; Vol 6, No 2, Prosiding Farmasi (Agustus, 2020); 872-878 |
|
| dc.source |
Prosiding Farmasi; Vol 6, No 2, Prosiding Farmasi (Agustus, 2020); 872-878 |
|
| dc.source |
2460-6472 |
|
| dc.source |
10.29313/.v6i2 |
|
| dc.subject |
Farmasi |
|
| dc.subject |
Ensefalitis, Hidroksiprolin, Reseptor NMDA |
|
| dc.title |
Uji In Silico Reaktivitas Reseptor NMDA (N-Metil-D-Aspartat) Ensefalitis terhadap Hidroksiprolin |
|
| dc.type |
info:eu-repo/semantics/article |
|
| dc.type |
info:eu-repo/semantics/publishedVersion |
|
| dc.type |
Peer-reviewed Article |
|
| dc.type |
Kuantitatif |
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