Abstract:
ABSTRACT: Cigarette smoke is a huge source of free radicals and high levels of chemicals. Exposure to cigarette smoke can cause inflammation and lung destruction. This study aims to look at the effect of ethanolic extracts of white oyster mushrooms in preventing the development
of lymphocyte infiltration in rats exposed to cigarette smoke. This experimental study used 32 rats divided into 4 groups. Group I (positive control, only given drinking water and standard food), group II (negative control) were given drinking water, standard food, and exposure to cigarette smoke 1 hour/day for 6 weeks. Group III (treatment group) were given cigarette smoke exposure 1 hour/day and ethanol extract of white oyster mushroom at a dose of 250 mg/KgBB of mice/day. Group IV (comparison group) were given cigarette smoke exposure 1 hour/day/group and were given N-acetyl cysteine at a dose of 600 mg/day. Lymphocyte infiltration can be seen from the histopathological picture of the rat lungs-stained by haematoxylin eosin staining. The results showed much of lymphocyte infiltration in rats exposed to cigarette smoke, but there was no significant difference in the proportion of lymphocyte infiltration between all groups (P= 0,14), which was assessed using fisher’s exact test. It can be concluded that ethanolic extracts of white oyster mushrooms can prevent development
of lymphocyte infiltration in rats exposed to cigarette smoke.
