The Role of Healing Effect of Lip Balm Application Cinnamomum burmannii on lip wound based on Immunohistochemical Interleukin 6 (IL-6) Levels

Abstract

The oral mucosa goes through a complicated series of biological healing processes to regain equilibrium after being injured. To heal wounds, we need a material that can heal wounds quickly and well. Cinnamon is widely used for therapy because it has good anti-bacterial, anti-inflammatory, and antioxidant effects. The purpose of this study was to analyze the healing effect of the application of lip balm Cinnamomum on lip incisions based on the level of immunohistochemical interleukin-6. This experimental study was conducted at the laboratory biomedical Faculty of Medicine, Universitas Islam Bandung. A 10 mm length and 4 mm depth incision lip mucous was surgically created in twenty-seven male rats with healthy, 200-300mg of body weight, male, 3-5 months. Animals were divided by simple random sampling were divided into three groups, group 1: the animal treated lip healing with distilled water (control). Group 2: the animal treat lip healing with placebo lip balm, and lastly, group 3: the animal treat lip healing with lip balm Cinnamomum burmannii. Each group performs observation on day-3, 7, and 14. To evaluate the effectiveness of treatment, a lip biopsy performs during each observation time. The immunoexpression IL-6 analysis was assessed by scoring distribution and intensity expression with a Leica microscope. There were significant differences in the level of immunoexpression Interleukin-6 in a group with treatment by lip balm Cinnamomum burmannii. By the time of observation, day 14 of group 2 have a greater level of IL-6 compared with the other groups. Application lip balm Cinnamomum burmanni is effective in faster and good remodeling lip healing process by seen increasing level of IL-6.