| dc.contributor |
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| dc.contributor |
1Prodi Pendidikan Dokter, Fakultas Kedokteran Universitas Islam Bandung, 2Departemen Farmakologi , Fakultas Kedokteran Universitas Islam Bandung, 3Departemen Neurologi, Fakultas Kedokteran Universitas Islam Bandung |
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| dc.creator |
Saboe, Muhammad Arga Putra |
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| dc.creator |
Sastramihardja, Herri |
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| dc.creator |
Saefulloh, Asep |
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| dc.date |
2017-08-10 |
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| dc.date.accessioned |
2019-09-13T05:58:09Z |
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| dc.date.available |
2019-09-13T05:58:09Z |
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| dc.identifier |
http://karyailmiah.unisba.ac.id/index.php/dokter/article/view/7880 |
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| dc.identifier.uri |
http://hdl.handle.net/123456789/25902 |
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| dc.description |
Treatment of diabetes mellitus (DM) is quite complex, thus requiring an alternative therapy for the patients with diabetes. Alternative treatments that can be used is a traditional medicinal plants. One of the traditional medicional plants that cant be used as antidiabetic drugs is Apium graveloens which contains flavonoid as an antidiabetic agent. The purpose of this research is to assess the effect of Apium graveolens ethanol extract in lowering fasting blood glucose (GDP). The research that has been conducted is an experimental study with a completely randomized design on 28 strains of Swiss Webster mice which were divided into 4 groups: group I (standard feed, alloxan), group II, III, IV (standard feed, alloxan, Apium graveolens extract 2,8 mg/ 20 g of body weight, 5,6 mg/ 20 g of body weight, 11,2 mg/ 20 g of body weight). The measurements were made after a period of adaptation, after alloxan induction and after 7 days of treatment. The research results after the Anova test with the significant value < 0.05 (0.015 < 0.05), thus showing that Apium graveolens extract with the dose of 5,6 mg/ 20 g of body weight, 5,6 mg/ 20 g of body weight,and 11,2 mg/ 20 g of body weight lower the level of GDP significantly. The further Anova test namely post hoc test showed that Apium graveolens with the dose of 5,6 mg/ 20 g of body weight extract has the highest decrease of GDP levels with 231,33 mg/dL. So that Apium graveolens extract with the dose of 5,6 mg/ 20 g of body weight is the effective dose in lowering the levels of GDP. The research conclusion showed that Apium graveolens ethanol extract can reduce the levels of GDP. |
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| dc.description |
Pengobatan Diabetes Melitus (DM) cukup kompleks, sehingga diperlukan alternatif terapi untuk penderita diabetes. Alternatif pengobatan yang bisa digunakan adalah tanaman obat tradisional. Salah satu tanaman obat tradisional yang dapat digunakan sebagai obat antidiabetes adalah daun seledri yang mengandung flavonoid sebagai zat antidiabetik. Tujuan penelitian ini untuk menilai efek pemberian ekstrak daun seledri dalam menurunkan glukosa darah puasa (GDP). Penelitian yang telah dilakukan bersifat eksperimental dengan rancangan acak lengkap terhadap 28 ekor mencit galur Swiss Webster yang terbagi 4 kelompok: kelompok I (pakan standar, aloksan), kelompok II, III, dan IV (pakan standar, aloksan, ekstrak etanol daun seledri 2,8 mg/ 20 g BB, 5,6 mg/ 20 g BB, 11,2 mg/ 20 g BB). Pengukuran dilakukan setelah masa adaptasi, setelah induksi aloksan dan setelah 7 hari perlakuan. Hasil penelitian setelah dilakukan uji Anava dengan nilai signifikan < 0.05 (0.015 < 0.05), sehingga menunjukkan bahwa ekstrak etanol daun seledri dosis 2,8 mg/ 20 g BB, 5,6 mg/ 20 g BB, dan 11,2 mg/ 20 g BB menurunkan kadar GDP secara signifikan. Uji lanjut Anava yaitu post hoc test menunjukkan bahwa ekstrak etanol daun seledri dosis 5,6 mg/ 20 g BB dapat menurunkan glukosa darah dengan kadar paling besar, yaitu 231,33 mg/dL, sehingga merupakan dosis efektif dalam menurunkan kadar GDP. Kesimpulan penelitian menunjukkan bahwa ekstrak etanol daun seledri dapat menurunkan kadar GDP. |
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| dc.format |
application/pdf |
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| dc.language |
ind |
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| dc.publisher |
Universitas Islam Bandung |
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| dc.relation |
http://karyailmiah.unisba.ac.id/index.php/dokter/article/view/7880/pdf |
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| dc.rights |
Copyright (c) 2017 Prosiding Pendidikan Dokter |
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| dc.source |
Prosiding Pendidikan Dokter; Vol 3, No 1, Prosiding Pendidikan Dokter (Agustus, 2017); 209-214 |
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| dc.source |
Prosiding Pendidikan Dokter; Vol 3, No 1, Prosiding Pendidikan Dokter (Agustus, 2017); 209-214 |
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| dc.source |
2460-657X |
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| dc.subject |
Medical Study |
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| dc.subject |
Diabetes Mellitus, Apium graveolens ethanol extract, Fasting Blood Glucose |
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| dc.subject |
Kedokteran |
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| dc.subject |
Diabetes melitus, Ekstrak etanol daun seledri, Glukosa darah puasa |
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| dc.title |
Effect of Ethanol Extract Celery (Apium graveolens) In Lowering Blood Glucose Levels Mice (Mus musculus) Diabetic Model |
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| dc.title |
Pengaruh Ekstrak Etanol Seledri ( Apium graveolens) Dalam Menurunkan Kadar Glukosa Darah Mencit ( Mus musculus) Model Diabetik |
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| dc.type |
info:eu-repo/semantics/article |
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| dc.type |
info:eu-repo/semantics/publishedVersion |
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| dc.type |
Peer-reviewed Article |
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| dc.type |
Quantitative |
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| dc.type |
Kuantitatif |
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