| dc.contributor |
|
|
| dc.contributor |
|
|
| dc.creator |
Vitaloka, Eneng Utari |
|
| dc.creator |
Yulianti, Arief Budi |
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| dc.creator |
Indrasari, Eva Rianti |
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| dc.date |
2017-08-14 |
|
| dc.date.accessioned |
2019-09-13T05:58:29Z |
|
| dc.date.available |
2019-09-13T05:58:29Z |
|
| dc.identifier |
http://karyailmiah.unisba.ac.id/index.php/dokter/article/view/8653 |
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| dc.identifier.uri |
http://hdl.handle.net/123456789/26163 |
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| dc.description |
Hypercholesterolemia is a major risk factor for coronary heart disease and stroke. Active compounds contained in ginger are gingerol, shogaol and niacin (B3) can potentially reduce total blood cholesterol levels. The purpose of this study is to know the effectiveness rhizome of elephant ginger (Zingiber officinale Rosc.) water extract to decrease total cholesterol blood levels in mice feed high-fat and induced propylthiouracil. The methode of this study was experimental with 30 male mice DDY strain fed high fat and induced propylthouracil 0.01% for 7 days in group II-VI. Elephant ginger rhizome warter extract was given at doses 28; 56; and 112 mg/kg weight with positive control of simvastatin 0,026 mg/kg weight. The result were analyzed by One Way ANOVA Test and followed by Post-Hoc test. The Result: decrease of average total cholesterol levels of group I-VI blood respectively: 1.40; 22.00; 65,60; 62,20; 62,20 and 58,60 mg/dL (p = 0,035). The treat elephant ginger rhizome water extract doses 28 mg/kg weight and 56mg/kg weight have similarity of simvastain effectivity doses 0,026 mg/kg weight, but in doses 112 mg/kg weight have least than effectivity so might be its doses optimum not clearly. Conclusion: elephant ginger rhizome water extract can decrease total cholesterol of mice blood induced propylthiouracil |
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| dc.description |
Hiperkolesterolemia merupakan faktor risiko utama dari penyakit jantung koroner dan stroke. Senyawa aktif yang terkandung dalam jahe yaitu gingerol, shogaol dan niasin (B3) berpotensi dapat menurunkan kadar kolesterol total darah. Tujuan penelitian untuk mengetahui efektifitas ekstrak air rimpang jahe gajah (Zingiber officinale Rosc.) terhadap penurunan kadar kolesterol total pada mencit yang diberi pakan tinggi lemak dan diinduksi propiltiourasil. Penelitian ini menggunakan metode eksperimental dengan 30 ekor mencit jantan galur DDY yang diberi pakan tinggi lemak dan diinduksi propiltiourasil 0,01% selama 7 hari pada kelompok II−VI. Ekstrak air rimpang jahe gajah diberikan dengan dosis 28; 56; dan 112 mg/kg Bobot dengan kontrol positif simvastatin 0,026 mg/kgBobot. Data hasil penelitian dianalisis dengan uji One Way ANOVA dan dilanjutkan dengan uji Post−Hoc. Hasil: rerata penurunan kadar kolesterol total darah kelompok I−VI berturutan: 1,40; 22,00; 65,60; 62,20; 62,20 dan 58,60 mg/dL (p=0,035). Pemberian ekstrak air rimpang jahe gajah dosis 28 mg/kg Bobot dan 56mg/kg Bobot mempunyai kemiripan efektivitas dengan simvastain dosi 0,026 mg/kg Bobot, namun pada dosis 112 mg/kg Bobot terjadi penurunan efektivitas sehingga dapat diduga terdapat dosis optimum yang belum diketahui dengan pasti. Simpulan: ekstrak air rimpang jahe gajah dapat menurunkan kadar kolesterol total darah mencit yang diinduksi propiltiourasil. |
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| dc.format |
application/pdf |
|
| dc.language |
ind |
|
| dc.publisher |
Universitas Islam Bandung |
|
| dc.relation |
http://karyailmiah.unisba.ac.id/index.php/dokter/article/view/8653/pdf |
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| dc.relation |
http://karyailmiah.unisba.ac.id/index.php/dokter/article/downloadSuppFile/8653/1493 |
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| dc.rights |
Copyright (c) 2017 Prosiding Pendidikan Dokter |
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| dc.source |
Prosiding Pendidikan Dokter; Vol 3, No 1, Prosiding Pendidikan Dokter (Agustus, 2017); 387-392 |
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| dc.source |
Prosiding Pendidikan Dokter; Vol 3, No 1, Prosiding Pendidikan Dokter (Agustus, 2017); 387-392 |
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| dc.source |
2460-657X |
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| dc.subject |
Medical Study |
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| dc.subject |
Elephant ginger rhizome water extract, cholesterol, propylthiouracil, simvastatin |
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| dc.subject |
Kedokteran |
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| dc.subject |
Ekstrak Air Rimpang Jahe Gajah, Kolesterol, Propiltiourasil, Simvastatin |
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| dc.title |
The Effectiveness of Elephant Ginger Rhizome (Zingiber officinale Rosc.) Water Extract to Decrease Total Blood Cholesterol Level on Mice Induced Propylthiouracil |
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| dc.title |
Efektivitas Ekstrak Air Rimpang Jahe Gajah (Zingiber officinale Rosc.) Terhadap Penurunan Kadar Kolesterol Total Darah Mencit yang Diinduksi Propiltiourasil |
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| dc.type |
info:eu-repo/semantics/article |
|
| dc.type |
info:eu-repo/semantics/publishedVersion |
|
| dc.type |
Peer-reviewed Article |
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| dc.type |
Quantitative |
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| dc.type |
Eksperimental labolatorik |
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