| dc.contributor |
Fakultas Matematika dan Ilmu Pengetahuan Alam |
|
| dc.creator |
Qalbiy, Nurul |
|
| dc.creator |
Fitrianingsih, Sri Peni |
|
| dc.creator |
Hazar, Siti |
|
| dc.date |
2020-08-25 |
|
| dc.date.accessioned |
2021-03-15T03:41:30Z |
|
| dc.date.available |
2021-03-15T03:41:30Z |
|
| dc.identifier |
http://karyailmiah.unisba.ac.id/index.php/farmasi/article/view/23616 |
|
| dc.identifier |
10.29313/.v6i2.23616 |
|
| dc.identifier.uri |
http://hdl.handle.net/123456789/28741 |
|
| dc.description |
Abstract. Depression is an emotional condition that occurs due to abnormality neurotransmitters of norepinephrine (NE), serotonin (5-HT) and dopamine (DA) in the brain. Natural substances that assumed have antidepressant activity and can increase mobility is bitter black honey with secondary metabolites of alkaloids. He purpose of this research is to investigate the effect of bitter black honey to the decrease in immobility time in Swiss Webster mice. This research used experimental method induced Chronic Mild Stress (CMS) with a total sample of 24 animals which that divided into 6 treatment groups. Antidepressant activity is measured based on the amount of immobility time decreased by the Forced Swimming Test (FST) method for last 4 minutes in 6 minutes. The results showed that the bitter black honey solution with a dose of 25 mg / 20 gBB, 50 mg / 20gBB and 100mg / 20gBB had significant different antidepressant activity (P <0,05) compared to the positive control group. Based on the research results an effective dosage of bitter black honey obtained at a dose of 25 mg/20 gBB because it can reduced the immobility duration measure of antidepressants.Keywords: Bitter Black Honey, Immobility Time, Forced Swimming Test (FST), Chronic Mild Stress (CMS)Abstrak. Depresi adalah kondisi emosional yang yang terjadi akibat ketidaknormalan pada kadar neurotransmitter norepinefrin (NE), serotonin (5-HT) dan dopamin (DA) didalam otak. Bahan alam yang diduga memiliki aktivitas antidepresan dan mampu meningkatkan mobilitas yaitu madu hitam pahit yang mengandung metabolit sekunder alkaloid. Penelitian ini bertujuan untuk membuktikan efek pemberian larutan madu hitam pahit terhadap penurunan immobility time pada mencit Swiss Webster. Penelitian ini dilakukan dengan metode eksperimental yang diinduksi Chronic Mild Stress (CMS) dengan jumlah sampel sebanyak 24 ekor yang dibagi dalam 6 kelompok perlakuan. Aktivitas antidepresan diukur berdasarkan jumlah penurunan immobility time dengan metode Forced Swimming Test (FST) pada 4 menit terakhir dari 6 menit. Hasil penelitian menunjukkan bahwa larutan madu hitam pahit dengan dosis 25 mg/20 gBB, 50 mg/20gBB dan 100mg/20gBB memiliki aktivitas antidepresan yang berbeda bermakna secara signifkan (P<0,05) dibandingkan dengan kelompok kontrol positif. Berdasarkan hasil penelitian dosis efektif sediaan larutan madu hitam pahit diperoleh pada dosis 25 mg/20 gBB karena mampu menurunkan durasi immobility time sebagai ukuran antidepresan.Kata Kunci: Madu Hitam Pahit, Waktu Imobilitas, Forced Swimming Test (FST), Chronic Mild Stress (CMS) |
|
| dc.format |
application/pdf |
|
| dc.language |
eng |
|
| dc.publisher |
Universitas Islam Bandung |
|
| dc.relation |
http://karyailmiah.unisba.ac.id/index.php/farmasi/article/view/23616/pdf |
|
| dc.rights |
Copyright (c) 2020 Prosiding Farmasi |
|
| dc.source |
Prosiding Farmasi; Vol 6, No 2, Prosiding Farmasi (Agustus, 2020); 663-667 |
|
| dc.source |
Prosiding Farmasi; Vol 6, No 2, Prosiding Farmasi (Agustus, 2020); 663-667 |
|
| dc.source |
2460-6472 |
|
| dc.source |
10.29313/.v6i2 |
|
| dc.subject |
Farmasi |
|
| dc.subject |
Madu Hitam Pahit, Waktu Imobilitas, Forced Swimming Test (FST), Chronic Mild Stress (CMS) |
|
| dc.title |
Uji Aktivitas Antidepresan dari Madu Hitam Pahit terhadap Mencit Swiss Webster yang Diinduksi dengan Chronic Mild Stress (CMS) |
|
| dc.type |
info:eu-repo/semantics/article |
|
| dc.type |
info:eu-repo/semantics/publishedVersion |
|
| dc.type |
Peer-reviewed Article |
|
| dc.type |
Kuantitatif |
|